Ontology highlight
ABSTRACT:
SUBMITTER: Duta-Mare M
PROVIDER: S-EPMC5839464 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Duta-Mare Madalina M Sachdev Vinay V Leopold Christina C Kolb Dagmar D Vujic Nemanja N Korbelius Melanie M Hofer Dina C DC Xia Wenmin W Huber Katharina K Auer Martina M Gottschalk Benjamin B Magnes Christoph C Graier Wolfgang F WF Prokesch Andreas A Radovic Branislav B Bogner-Strauss Juliane G JG Kratky Dagmar D
Biochimica et biophysica acta. Molecular and cell biology of lipids 20180131 4
Lysosomal acid lipase (LAL) is the only known enzyme, which hydrolyzes cholesteryl esters and triacylglycerols in lysosomes of multiple cells and tissues. Here, we explored the role of LAL in brown adipose tissue (BAT). LAL-deficient (Lal-/-) mice exhibit markedly reduced UCP1 expression in BAT, modified BAT morphology with accumulation of lysosomes, and mitochondrial dysfunction, consequently leading to regular hypothermic events in mice kept at room temperature. Cold exposure resulted in reduc ...[more]