Ontology highlight
ABSTRACT:
SUBMITTER: Ran L
PROVIDER: S-EPMC6545351 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Ran Liyuan L Wang Xiaoshuang X Mi Ai A Liu Yanshuang Y Wu Jin J Wang Haoan H Guo Meihua M Sun Jie J Liu Bo B Li Youwei Y Wang Dan D Jiang Rujiao R Wang Ning N Gao Wenting W Zeng Li L Huang Lin L Chen Xiaoli X LeRoith Derek D Liang Bin B Li Xin X Wu Yingjie Y
iScience 20190516
Growth hormone (GH) binds to its receptor (growth hormone receptor [GHR]) to exert its pleiotropic effects on growth and metabolism. Disrupted GH/GHR actions not only fail growth but also are involved in many metabolic disorders, as shown in murine models with global or tissue-specific Ghr deficiency and clinical observations. Here we constructed an adipose-specific Ghr knockout mouse model Ad-GHRKO and studied the metabolic adaptability of the mice when stressed by high-fat diet (HFD) or cold. ...[more]