Ontology highlight
ABSTRACT:
SUBMITTER: Verweij FJ
PROVIDER: S-EPMC5839777 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Verweij Frederik Johannes FJ Bebelman Maarten P MP Jimenez Connie R CR Garcia-Vallejo Juan J JJ Janssen Hans H Neefjes Jacques J Knol Jaco C JC de Goeij-de Haas Richard R Piersma Sander R SR Baglio S Rubina SR Verhage Matthijs M Middeldorp Jaap M JM Zomer Anoek A van Rheenen Jacco J Coppolino Marc G MG Hurbain Ilse I Raposo Graça G Smit Martine J MJ Toonen Ruud F G RFG van Niel Guillaume G Pegtel D Michiel DM
The Journal of cell biology 20180116 3
Exosomes are small endosome-derived extracellular vesicles implicated in cell-cell communication and are secreted by living cells when multivesicular bodies (MVBs) fuse with the plasma membrane (PM). Current techniques to study exosome physiology are based on isolation procedures after secretion, precluding direct and dynamic insight into the mechanics of exosome biogenesis and the regulation of their release. In this study, we propose real-time visualization of MVB-PM fusion to overcome these l ...[more]