Ontology highlight
ABSTRACT:
SUBMITTER: Kumar S
PROVIDER: S-EPMC5839791 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Kumar Suresh S Kumar Suresh S Jain Ashish A Farzam Farzin F Jia Jingyue J Gu Yuexi Y Choi Seong Won SW Mudd Michal H MH Claude-Taupin Aurore A Wester Michael J MJ Lidke Keith A KA Rusten Tor-Erik TE Deretic Vojo V
The Journal of cell biology 20180202 3
Autophagy is a conserved eukaryotic process with metabolic, immune, and general homeostatic functions in mammalian cells. Mammalian autophagosomes fuse with lysosomes in a SNARE-driven process that includes syntaxin 17 (Stx17). How Stx17 translocates to autophagosomes is unknown. In this study, we show that the mechanism of Stx17 recruitment to autophagosomes in human cells entails the small guanosine triphosphatase IRGM. Stx17 directly interacts with IRGM, and efficient Stx17 recruitment to aut ...[more]