Ontology highlight
ABSTRACT:
SUBMITTER: Gu Y
PROVIDER: S-EPMC6856626 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Gu Yuexi Y Princely Abudu Yakubu Y Kumar Suresh S Bissa Bhawana B Choi Seong Won SW Jia Jingyue J Lazarou Michael M Eskelinen Eeva-Liisa EL Johansen Terje T Deretic Vojo V
The EMBO journal 20191018 22
Mammalian homologs of yeast Atg8 protein (mAtg8s) are important in autophagy, but their exact mode of action remains ill-defined. Syntaxin 17 (Stx17), a SNARE with major roles in autophagy, was recently shown to bind mAtg8s. Here, we identified LC3-interacting regions (LIRs) in several SNAREs that broaden the landscape of the mAtg8-SNARE interactions. We found that Syntaxin 16 (Stx16) and its cognate SNARE partners all have LIR motifs and bind mAtg8s. Knockout of Stx16 caused defects in lysosome ...[more]