Ontology highlight
ABSTRACT:
SUBMITTER: Bartelt A
PROVIDER: S-EPMC5839993 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Bartelt Alexander A Widenmaier Scott B SB Schlein Christian C Johann Kornelia K Goncalves Renata L S RLS Eguchi Kosei K Fischer Alexander W AW Parlakgül Günes G Snyder Nicole A NA Nguyen Truc B TB Bruns Oliver T OT Franke Daniel D Bawendi Moungi G MG Lynes Matthew D MD Leiria Luiz O LO Tseng Yu-Hua YH Inouye Karen E KE Arruda Ana Paula AP Hotamisligil Gökhan S GS
Nature medicine 20180205 3
Adipocytes possess remarkable adaptive capacity to respond to nutrient excess, fasting or cold exposure, and they are thus an important cell type for the maintenance of proper metabolic health. Although the endoplasmic reticulum (ER) is a critical organelle for cellular homeostasis, the mechanisms that mediate adaptation of the ER to metabolic challenges in adipocytes are unclear. Here we show that brown adipose tissue (BAT) thermogenic function requires an adaptive increase in proteasomal activ ...[more]