Ontology highlight
ABSTRACT:
SUBMITTER: Branca RT
PROVIDER: S-EPMC4273360 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Branca Rosa Tamara RT He Ting T Zhang Le L Floyd Carlos S CS Freeman Matthew M White Christian C Burant Alex A
Proceedings of the National Academy of Sciences of the United States of America 20141201 50
The study of brown adipose tissue (BAT) in human weight regulation has been constrained by the lack of a noninvasive tool for measuring this tissue and its function in vivo. Existing imaging modalities are nonspecific and intrinsically insensitive to the less active, lipid-rich BAT of obese subjects, the target population for BAT studies. We demonstrate noninvasive imaging of BAT in mice by hyperpolarized xenon gas MRI. We detect a greater than 15-fold increase in xenon uptake by BAT during stim ...[more]