Ontology highlight
ABSTRACT:
SUBMITTER: Jang Y
PROVIDER: S-EPMC5840015 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Jang Youngsoon Y Gerbec Zachary J ZJ Won Taejoon T Choi Bongkum B Podsiad Amy A B Moore Bethany B Malarkannan Subramaniam S Laouar Yasmina Y
Journal of immunology (Baltimore, Md. : 1950) 20180209 6
B6.SJL-<i>Ptprc<sup>a</sup> Pepc<sup>b</sup></i> /Boy (CD45.1) mice have been used in hundreds of congenic competitive transplants, with the presumption that they differ from C57BL/6 mice only at the CD45 locus. In this study, we describe a point mutation in the natural cytotoxicity receptor 1 (<i>Ncr1</i>) locus fortuitously identified in the CD45.1 strain. This point mutation was mapped at the 40th nucleotide of the <i>Ncr1</i> locus causing a single amino acid mutation from cysteine to argini ...[more]