Ontology highlight
ABSTRACT:
SUBMITTER: Gorges K
PROVIDER: S-EPMC6896052 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Gorges Katharina K Wiltfang Lisa L Gorges Tobias M TM Sartori Alexander A Hildebrandt Lina L Keller Laura L Volkmer Beate B Peine Sven S Babayan Anna A Moll Ingrid I Schneider Stefan W SW Twarock Sören S Mohr Peter P Fischer Jens W JW Pantel Klaus K
Cancers 20191029 11
Despite remarkable progress in melanoma therapy, the exceptional heterogeneity of the disease has prevented the development of reliable companion biomarkers for the prediction or monitoring of therapy responses. Here, we show that difficulties in detecting blood-based markers, like circulating tumor cells (CTC), might arise from the translation of the mutational heterogeneity of melanoma cells towards their surface marker expression. We provide a unique method, which enables the molecular charac ...[more]