Ontology highlight
ABSTRACT:
SUBMITTER: Widlansky ME
PROVIDER: S-EPMC5840545 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Widlansky Michael E ME Jensen David M DM Wang Jingli J Liu Yong Y Geurts Aron M AM Kriegel Alison J AJ Liu Pengyuan P Ying Rong R Zhang Guangyuan G Casati Marc M Chu Chen C Malik Mobin M Branum Amberly A Tanner Michael J MJ Tyagi Sudhi S Usa Kristie K Liang Mingyu M
EMBO molecular medicine 20180301 3
We investigated the role of microRNAs (miRNA) in endothelial dysfunction in the setting of cardiometabolic disorders represented by type 2 diabetes mellitus (T2DM). miR-29 was dysregulated in resistance arterioles obtained by biopsy in T2DM patients. Intraluminal delivery of miR-29a-3p or miR-29b-3p mimics restored normal endothelium-dependent vasodilation (EDVD) in T2DM arterioles that otherwise exhibited impaired EDVD Intraluminal delivery of anti-miR-29b-3p in arterioles from non-DM human sub ...[more]