Ontology highlight
ABSTRACT:
SUBMITTER: Carreras-Gonzalez A
PROVIDER: S-EPMC5841238 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Carreras-González Ana A Navasa Nicolás N Martín-Ruiz Itziar I Lavín José Luis JL Azkargorta Mikel M Atondo Estíbaliz E Barriales Diego D Macías-Cámara Nuria N Pascual-Itoiz Miguel Angel MA Sampedro Leticia L Tomás-Cortázar Julen J Peña-Cearra Ainize A Pellón Aize A Prados-Rosales Rafael R Abecia Leticia L Elortza Félix F Aransay Ana M AM Rodríguez Héctor H Anguita Juan J
Emerging microbes & infections 20180307 1
Macrophages are cells of the innate immune system with the ability to phagocytose and induce a global pattern of responses that depend on several signaling pathways. We have determined the biosignature of murine bone marrow-derived macrophages and human blood monocytes using transcriptomic and proteomic approaches. We identified a common pattern of genes that are transcriptionally regulated and overall indicate that the response to B. burgdorferi involves the interaction of spirochetal antigens ...[more]