Ontology highlight
ABSTRACT:
SUBMITTER: Teo AKK
PROVIDER: S-EPMC5841351 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Teo Adrian Keong Kee AKK Lim Chang Siang CS Cheow Lih Feng LF Kin Tatsuya T Shapiro James A JA Kang Nam-Young NY Burkholder William W Lau Hwee Hui HH
Cell death discovery 20180209
Human pancreatic islets containing insulin-secreting β-cells are notoriously heterogeneous in cell composition. Since β-cell failure is the root cause of diabetes, understanding this heterogeneity is of paramount importance. Recent reports have cataloged human islet transcriptome but not compared single β-cells in detail. Here, we scrutinized ex vivo human islet cells from healthy donors and show that they exhibit de-differentiation signatures. Using single-cell gene expression and immunostainin ...[more]