Ontology highlight
ABSTRACT:
SUBMITTER: Zhang C
PROVIDER: S-EPMC5841608 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Zhang Cheng C Skamagki Maria M Liu Zhong Z Ananthanarayanan Aparna A Zhao Rui R Li Hu H Kim Kitai K
Cell reports 20171101 8
We discovered that induced pluripotent stem cell (iPSC) clones generated from aged tissue donors (A-iPSCs) fail to suppress oxidative phosphorylation. Compared to embryonic stem cells (ESCs) and iPSCs generated from young donors (Y-iPSCs), A-iPSCs show poor expression of the pluripotent stem cell-specific glucose transporter 3 (GLUT3) and impaired glucose uptake, making them unable to support the high glucose demands of glycolysis. Persistent oxidative phosphorylation in A-iPSCs generates higher ...[more]