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ABSTRACT: Objectives
To determine the prevalence and severity of neuropathic pain, sudomotor dysfunction and abnormal vibration perception in patients with MS.Methods
73 patients with MS and 32 age-matched healthy controls underwent assessment of expanded disability severity score (EDSS), DN4 to assess neuropathic pain, electrochemical skin conductance (ESC) to assess sudomotor function and vibration perception threshold (VPT).Results
Patients with MS had a higher DN4 score (p < 0.001) with 14% fulfilling the criteria for neuropathic pain elevated VPT (p < 0.001) and lower ESC on the feet (p < 0.001) and hands (p < 0.001) compared to control participants. ESC on the feet (32% of MS patients) and hands (30% of MS patients) were lower, and DN4 (77% of MS patients) and VPT (64% of MS patients) were greater than 2SD of the healthy control values, respectively. EDSS correlated with the number of relapses (r = 0.564, p < 0.001), VPT (r = -0.457, < 0.001) and ESC on the feet (r = -0.268, p = 0.023).Conclusions
Patients with multiple sclerosis have evidence of sudomotor dysfunction and elevated vibration perception, which were associated with neurological disability from MS.
SUBMITTER: Khan A
PROVIDER: S-EPMC5841750 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Khan Adnan A Kamran Saadat S Ponirakis Georgios G Akhtar Naveed N Khan Rabia R George Pooja P Babu Blessy M BM Ibrahim Faiza M FM Petropoulos Ioannis N IN Canibano Beatriz G BG Wilins Stacy S SS Deleu Dirk D Shuaib Ashfaq A Malik Rayaz A RA
PloS one 20180307 3
<h4>Objectives</h4>To determine the prevalence and severity of neuropathic pain, sudomotor dysfunction and abnormal vibration perception in patients with MS.<h4>Methods</h4>73 patients with MS and 32 age-matched healthy controls underwent assessment of expanded disability severity score (EDSS), DN4 to assess neuropathic pain, electrochemical skin conductance (ESC) to assess sudomotor function and vibration perception threshold (VPT).<h4>Results</h4>Patients with MS had a higher DN4 score (p < 0. ...[more]