Ontology highlight
ABSTRACT:
SUBMITTER: Beckford Vera DR
PROVIDER: S-EPMC5841805 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Beckford Vera Denis R DR Smith Christof C CC Bixby Lisa M LM Glatt Dylan M DM Dunn Stuart S SS Saito Ryoichi R Kim William Y WY Serody Jonathan S JS Vincent Benjamin G BG Parrott Matthew C MC
PloS one 20180307 3
The ability to non-invasively monitor tumor-infiltrating T cells in vivo could provide a powerful tool to visualize and quantify tumor immune infiltrates. For non-invasive evaluations in vivo, an anti-CD3 mAb was modified with desferrioxamine (DFO) and radiolabeled with zirconium-89 (Zr-89 or 89Zr). Radiolabeled 89Zr-DFO-anti-CD3 was tested for T cell detection using positron emission tomography (PET) in both healthy mice and mice bearing syngeneic bladder cancer BBN975. In vivo PET/CT and ex vi ...[more]