Automated light-induced synthesis of ⁸⁹Zr-radiolabeled antibodies for immuno-positron emission tomography.

ABSTRACT: Clinical production of ⁸⁹Zr-radiolabeled antibodies (⁸⁹Zr-mAbs) for positron emission tomography imaging relies on the pre-conjugation of desferrioxamine B (DFO) to the purified protein, followed by isolation and characterization of the functionalized intermediate, and then manual radiosynthesis. Although highly successful, this route exposes radiochemists to a potentially large radiation dose and entails several technological and economic hurdles that limit access of ⁸⁹Zr-mAbs to just a specialist few Nuclear Medicine facilities worldwide. Here, we introduce a fully automated synthesis box that can produce individual doses of ⁸⁹Zr-mAbs formulated in sterile solution in < 25 min starting from [⁸⁹Zr(C₂O₄)₄

SUBMITTER: Klingler S 

PROVIDER: S-EPMC8758695 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature