Ontology highlight
ABSTRACT: Background
A percent brain volume change (PBVC) cut-off of -0.4% per year has been proposed to distinguish between pathological and physiological changes in multiple sclerosis (MS). Unfortunately, standardized PBVC measurement is not always feasible on scans acquired outside research studies or academic centers. Percent lateral ventricular volume change (PLVVC) is a strong surrogate measure of PBVC, and may be more feasible for atrophy assessment on real-world scans. However, the PLVVC rate corresponding to the established PBVC cut-off of -0.4% is unknown.Objective
To establish a pathological PLVVC expansion rate cut-off analogous to -0.4% PBVC.Methods
We used three complementary approaches. First, the original follow-up-length-weighted receiver operating characteristic (ROC) analysis method establishing whole brain atrophy rates was adapted to a longitudinal ventricular atrophy dataset of 177 relapsing-remitting MS (RRMS) patients and 48 healthy controls. Second, in the same dataset, SIENA PBVCs were used with non-linear regression to directly predict the PLVVC value corresponding to -0.4% PBVC. Third, in an unstandardized, real world dataset of 590 RRMS patients from 33 centers, the cut-off maximizing correspondence to PBVC was found. Finally, correspondences to clinical outcomes were evaluated in both datasets.Results
ROC analysis suggested a cut-off of 3.09% (AUC?=?0.83, p?2 was 0.71 (p?ConclusionsVentricular expansion of between 3.09% and 3.51% on T2-FLAIR corresponds to the pathological whole brain atrophy rate of 0.4% for RRMS. A conservative cut-off of 3.5% performs comparably to PBVC for clinical outcomes.
SUBMITTER: Dwyer MG
PROVIDER: S-EPMC5842310 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Dwyer Michael G MG Hagemeier Jesper J Bergsland Niels N Horakova Dana D Korn Jonathan R JR Khan Nasreen N Uher Tomas T Medin Jennie J Silva Diego D Vaneckova Manuela M Havrdova Eva Kubala EK Zivadinov Robert R
NeuroImage. Clinical 20180207
<h4>Background</h4>A percent brain volume change (PBVC) cut-off of -0.4% per year has been proposed to distinguish between pathological and physiological changes in multiple sclerosis (MS). Unfortunately, standardized PBVC measurement is not always feasible on scans acquired outside research studies or academic centers. Percent lateral ventricular volume change (PLVVC) is a strong surrogate measure of PBVC, and may be more feasible for atrophy assessment on real-world scans. However, the PLVVC r ...[more]