Ontology highlight
ABSTRACT:
SUBMITTER: Jiang C
PROVIDER: S-EPMC5842788 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Jiang Changying C Zhou Zhicheng Z Quan Yanping Y Zhang Shilei S Wang Tingting T Zhao Xueqiang X Morrison Clayton C Heise Mark T MT He Wenqian W Miller Matthew S MS Lin Xin X
Cell reports 20160303 10
Host response to RNA virus infection is sensed by RNA sensors such as RIG-I, which induces MAVS-mediated NF-κB and IRF3 activation to promote inflammatory and antiviral responses, respectively. Here, we have found that CARMA3, a scaffold protein previously shown to mediate NF-κB activation induced by GPCR and EGFR, positively regulates MAVS-induced NF-κB activation. However, our data suggest that CARMA3 sequesters MAVS from forming high-molecular-weight aggregates, thereby suppressing TBK1/IRF3 ...[more]