Plasma citrate concentration: a possible biomarker for glaucoma in children.

ABSTRACT: Objectives:The main aim of the present study was to examine a possible role of plasma and urine citrate levels as glaucoma indicators in school-aged children with glaucoma diagnosis. Patients:34 school-aged children with a glaucoma diagnosis (mean age 15.69±1.86 years) were qualified for the study group and 34 patients with no ophthalmological ailments were qualified for the control group (mean age 16.1±1.98 years). Plasma and urine citrate levels in the study and the control group (Kruskal-Wallis test) were compared. Results:Plasma citrate levels in the study (16.33±4.51?mg/L) and the control group (19.11±3.66?mg/L) were different; the statistical significance (p=0.0036). Plasma citrate concentrations were significantly lower in the study group in comparison with the control group. There were no statistically important differences between the study group (291.12±259.13?mg/24?hours; 275.82±217.57?mg/g) and the control group (434.88±357.66?mg/24?hours; 329.81±383.27?mg/g) including urine citrate level (p=0.052) and urine citrate to creatine ratio (p=0.4667). Conclusion:Plasma citrate concentration might be considered as glaucoma biomarker in paediatric population.

SUBMITTER: Michalczuk M 

PROVIDER: S-EPMC5843004 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature