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Modulation of plasma triglycerides concentration by sterol-based treatment in children carrying different genes.

ABSTRACT: Background:Dyslipidemias have increased during the last decades in children. Aim:The objective of this study was to analyze the influence of different polymorphisms in plasma triglyceride levels of children following a dietary treatment with plant sterols. Design:A randomized, double-blind, crossover, controlled clinical trial was carried out in 26 children (16 women). Materials and Methods:Commercial milk, with 2.24 g sterols, was ingested daily during 3 weeks , and the same amount of kimmed milk without sterols, during the 3 week placebo phase. Both phases were separated by a washout period of 2 weeks. At the beginning and end of each phase, blood draws were performed. Results:Apolipoprotein A5 Ser19Trp (P = 0.002), peroxisome proliferator-activated receptor-alpha L162V (P = 0.003), APOE APOE2/3/4 (P = 0.012), and APOE APOE2,3,4 (P = 0.025) show statistically significant differences between their haplotypes in plasma triglyceride levels. Other genes did not show statistically significant differences. Conclusions:Further studies are needed to establish which genotype combinations would be the most protective against hypertriglyceridemia.

SUBMITTER: San Mauro Martin I

PROVIDER: S-EPMC6521671 | biostudies-literature | 2019 May-Aug

REPOSITORIES: biostudies-literature

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Modulation of plasma triglycerides concentration by sterol-based treatment in children carrying different genes.

San Mauro Martín Ismael I Sanz Rojo Sara S Garicano Vilar Elena E Collado Yurrita Luis L Blumenfeld Olivares Javier Andrés JA

Annals of pediatric cardiology 20190501 2

<h4>Background</h4>Dyslipidemias have increased during the last decades in children.<h4>Aim</h4>The objective of this study was to analyze the influence of different polymorphisms in plasma triglyceride levels of children following a dietary treatment with plant sterols.<h4>Design</h4>A randomized, double-blind, crossover, controlled clinical trial was carried out in 26 children (16 women).<h4>Materials and methods</h4>Commercial milk, with 2.24 g sterols, was ingested daily during 3 weeks , and ...[more]

PMID: 31143031

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Project description:BackgroundFood insecurity and metabolic diseases both disproportionately affect Hispanic children. Cross-sectional studies have linked food insecurity with adverse cardiometabolic markers, including elevated plasma triglycerides and glucose concentrations. However, the association between changes in food insecurity and changes in cardiometabolic markers in children remains to be explored. Furthermore, few studies have assessed the impact of school-based nutrition interventions on household food insecurity.ObjectiveThe objectives of this study are to assess the effect of the TX Sprouts intervention on household food insecurity and to examine the association between changes in household food insecurity and changes in cardiometabolic markers over 1 academic year.MethodsThis secondary analysis used data from TX Sprouts, a cluster-randomized school-based gardening, cooking, and nutrition trial. The study enrolled 3rd-5th-grade students from 16 schools that served primarily (>50%) Hispanic families with low income in Austin, TX. Participants (n = 619) provided household food insecurity data and fasting lipid panels at both baseline and postintervention, ∼9 mo following.ResultsThere was no intervention effect on household food insecurity. Independent of the intervention, a 1-point increase in food insecurity, indicative of becoming more food insecure, was associated with a 2.61 mg/dL increase in triglycerides (P = 0.001; 95% CI: 1.04, 4.19) at follow-up. Children who were food insecure at baseline and became food secure at follow-up had a mean 5.05 mg/dL decrease in triglycerides compared with a 7.50 mg/dL increase in triglycerides in children who remained food insecure throughout (95% CI: -23.40, -1.71, P = 0.023). There were no other associations between changes in food insecurity and cardiometabolic markers.ConclusionAlthough the intervention did not improve food insecurity, reductions in food insecurity over 9 mo were associated with improved cardiometabolic markers in high-risk children, emphasizing the need for interventions targeting food insecurity. The study is registered at clinicaltrials.gov under NCT02668744 (https://classic.Clinicaltrialsgov/ct2/show/NCT02668744).

Dataset Information

Modulation of plasma triglycerides concentration by sterol-based treatment in children carrying different genes.

Publications

Modulation of plasma triglycerides concentration by sterol-based treatment in children carrying different genes.

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