Ontology highlight
ABSTRACT:
SUBMITTER: You S
PROVIDER: S-EPMC5844331 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Genetics 20180301 3
We describe a genome-wide microRNA (miRNA)-based screen to identify brain glial cell functions required for circadian behavior. To identify glial miRNAs that regulate circadian rhythmicity, we employed a collection of "miR-sponges" to inhibit miRNA function in a glia-specific manner. Our initial screen identified 20 glial miRNAs that regulate circadian behavior. We studied two miRNAs, miR-263b and miR-274, in detail and found that both function in adult astrocytes to regulate behavior. Astrocyte ...[more]