Ontology highlight
ABSTRACT:
SUBMITTER: Li Q
PROVIDER: S-EPMC5845385 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Li Qingcui Q Dai Chengliang C Xue Rui R Wang Peigang P Chen Lin L Han Yijie Y Erben Ulrike U Qin Zhihai Z
Frontiers in immunology 20180305
Myeloid-derived suppressor cells (MDSCs) often expand during cancer or chronic inflammation and dampen immune responses. However, mechanisms underlying their capacity to escape intrinsic apoptosis in the inflammatory environment are still largely unknown. In this study, we investigated this in mouse tumor models with MDSC accumulation. Spontaneous rejection of tumors implanted into mice deficient for the small Ca<sup>2+</sup>-binding protein S100A4 (S100A4<sup>-/-</sup>) was accompanied by low n ...[more]