Ontology highlight
ABSTRACT:
SUBMITTER: Behrens AJ
PROVIDER: S-EPMC5846105 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Behrens Anna-Janina AJ Kumar Abhinav A Medina-Ramirez Max M Cupo Albert A Marshall Kevin K Cruz Portillo Victor M VM Harvey David J DJ Ozorowski Gabriel G Zitzmann Nicole N Wilson Ian A IA Ward Andrew B AB Struwe Weston B WB Moore John P JP Sanders Rogier W RW Crispin Max M
Journal of proteome research 20180208 3
Broadly neutralizing antibodies (bNAbs) that target the trimeric HIV-1 envelope glycoprotein spike (Env) are tools that can guide the design of recombinant Env proteins intended to engage the predicted human germline precursors of bNAbs (gl-bNAbs). The protein components of gl-bNAb epitopes are often masked by glycans, while mature bNAbs can evolve to accommodate or bypass these shielding glycans. The design of germline-targeting Env immunogens therefore includes the targeted deletion of specifi ...[more]