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Juicer Provides a One-Click System for Analyzing Loop-Resolution Hi-C Experiments.

ABSTRACT: Hi-C experiments explore the 3D structure of the genome, generating terabases of data to create high-resolution contact maps. Here, we introduce Juicer, an open-source tool for analyzing terabase-scale Hi-C datasets. Juicer allows users without a computational background to transform raw sequence data into normalized contact maps with one click. Juicer produces a hic file containing compressed contact matrices at many resolutions, facilitating visualization and analysis at multiple scales. Structural features, such as loops and domains, are automatically annotated. Juicer is available as open source software at http://aidenlab.org/juicer/.

SUBMITTER: Durand NC

PROVIDER: S-EPMC5846465 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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Juicer Provides a One-Click System for Analyzing Loop-Resolution Hi-C Experiments.

Durand Neva C NC Shamim Muhammad S MS Machol Ido I Rao Suhas S P SS Huntley Miriam H MH Lander Eric S ES Aiden Erez Lieberman EL

Cell systems 20160701 1

Hi-C experiments explore the 3D structure of the genome, generating terabases of data to create high-resolution contact maps. Here, we introduce Juicer, an open-source tool for analyzing terabase-scale Hi-C datasets. Juicer allows users without a computational background to transform raw sequence data into normalized contact maps with one click. Juicer produces a hic file containing compressed contact matrices at many resolutions, facilitating visualization and analysis at multiple scales. Struc ...[more]

PMID: 27467249

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