Ontology highlight
ABSTRACT:
SUBMITTER: Aguado LC
PROVIDER: S-EPMC5846625 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Aguado Lauren C LC Schmid Sonja S May Jared J Sabin Leah R LR Panis Maryline M Blanco-Melo Daniel D Shim Jaehee V JV Sachs David D Cherry Sara S Simon Anne E AE Levraud Jean-Pierre JP tenOever Benjamin R BR
Nature 20170628 7661
In contrast to the DNA-based viruses in prokaryotes, the emergence of eukaryotes provided the necessary compartmentalization and membranous environment for RNA viruses to flourish, creating the need for an RNA-targeting antiviral system. Present day eukaryotes employ at least two main defence strategies that emerged as a result of this viral shift, namely antiviral RNA interference and the interferon system. Here we demonstrate that Drosha and related RNase III ribonucleases from all three domai ...[more]