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Multicomponent synthesis of artificial nucleases and their RNase and DNase activity.

ABSTRACT: The synthesis of new, artificial ribonucleases containing two amino acid residues connected by an aliphatic linker has been developed. Target molecules were synthesized via a catalytic three-component Ugi reaction from aliphatic diisocyanides. Preliminary investigations proved unspecific nuclease activity of the new compounds towards single-stranded RNA and double-stranded circular DNA.

SUBMITTER: Gulevich AV

PROVIDER: S-EPMC3170195 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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Multicomponent synthesis of artificial nucleases and their RNase and DNase activity.

Gulevich Anton V AV Koroleva Lyudmila S LS Morozova Olga V OV Bakhvalova Valentina N VN Silnikov Vladimir N VN Nenajdenko Valentine G VG

Beilstein journal of organic chemistry 20110819

The synthesis of new, artificial ribonucleases containing two amino acid residues connected by an aliphatic linker has been developed. Target molecules were synthesized via a catalytic three-component Ugi reaction from aliphatic diisocyanides. Preliminary investigations proved unspecific nuclease activity of the new compounds towards single-stranded RNA and double-stranded circular DNA. ...[more]

PMID: 21915218

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