Ontology highlight
ABSTRACT:
SUBMITTER: Sonnen KF
PROVIDER: S-EPMC5847172 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Sonnen Katharina F KF Lauschke Volker M VM Uraji Julia J Falk Henning J HJ Petersen Yvonne Y Funk Maja C MC Beaupeux Mathias M François Paul P Merten Christoph A CA Aulehla Alexander A
Cell 20180201 5
How signaling dynamics encode information is a central question in biology. During vertebrate development, dynamic Notch signaling oscillations control segmentation of the presomitic mesoderm (PSM). In mouse embryos, this molecular clock comprises signaling oscillations of several pathways, i.e., Notch, Wnt, and FGF signaling. Here, we directly address the role of the relative timing between Wnt and Notch signaling oscillations during PSM patterning. To this end, we developed a new experimental ...[more]