Ontology highlight
ABSTRACT:
SUBMITTER: Baron JW
PROVIDER: S-EPMC6893488 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Baron Joseph W JW Galla Tobias T
Journal of the Royal Society, Interface 20191127 160
Using a stochastic individual-based modelling approach, we examine the role that Delta-Notch signalling plays in the regulation of a robust and reliable somite segmentation clock. We find that not only can Delta-Notch signalling synchronize noisy cycles of gene expression in adjacent cells in the presomitic mesoderm (as is known), but it can also amplify and increase the coherence of these cycles. We examine some of the shortcomings of deterministic approaches to modelling these cycles and demon ...[more]