Ontology highlight
ABSTRACT:
SUBMITTER: Doyle S
PROVIDER: S-EPMC5847599 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Doyle Sean S Hansen Daniel Bloch DB Vella Jasmine J Bond Peter P Harper Glenn G Zammit Christian C Valentino Mario M Fern Robert R
Nature communications 20180312 1
The axon myelin sheath is prone to injury associated with N-methyl-D-aspartate (NMDA)-type glutamate receptor activation but the source of glutamate in this context is unknown. Myelin damage results in permanent action potential loss and severe functional deficit in the white matter of the CNS, for example in ischemic stroke. Here, we show that in rats and mice, ischemic conditions trigger activation of myelinic NMDA receptors incorporating GluN2C/D subunits following release of axonal vesicular ...[more]