Ontology highlight
ABSTRACT:
SUBMITTER: Havens PL
PROVIDER: S-EPMC5848310 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Havens Peter L PL Stephensen Charles B CB Van Loan Marta D MD Schuster Gertrud U GU Woodhouse Leslie R LR Flynn Patricia M PM Gordon Catherine M CM Pan Cynthia G CG Rutledge Brandy B Harris D Robert DR Price Georgine G Baker Alyne A Meyer William A WA Wilson Craig M CM Hazra Rohan R Kapogiannis Bill G BG Mulligan Kathleen K
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20180101 2
<h4>Background</h4>Tenofovir disoproxil fumarate (TDF) decreases bone mineral density (BMD). We hypothesized that vitamin D3 (VITD3) would increase BMD in youth receiving TDF.<h4>Methods</h4>This was a randomized, double-blind, placebo-controlled trial of directly observed VITD3 vs placebo every 4 weeks for 48 weeks in youth aged 16-24 years with HIV, RNA load <200 copies/mL, taking TDF-containing combination antiretroviral therapy (TDF-cART) for ≥180 days. Participants (N = 214) received a dail ...[more]