Ontology highlight
ABSTRACT:
SUBMITTER: Takaku M
PROVIDER: S-EPMC5849768 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Takaku Motoki M Grimm Sara A SA Roberts John D JD Chrysovergis Kaliopi K Bennett Brian D BD Myers Page P Perera Lalith L Tucker Charles J CJ Perou Charles M CM Wade Paul A PA
Nature communications 20180313 1
GATA3 is frequently mutated in breast cancer; these mutations are widely presumed to be loss-of function despite a dearth of information regarding their effect on disease course or their mechanistic impact on the breast cancer transcriptional network. Here, we address molecular and clinical features associated with GATA3 mutations. A novel classification scheme defines distinct clinical features for patients bearing breast tumors with mutations in the second GATA3 zinc-finger (ZnFn2). An enginee ...[more]