Ontology highlight
ABSTRACT:
SUBMITTER: Liu XS
PROVIDER: S-EPMC5817916 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Oncogene 20151012 23
We recently reported that ZBTB7A is a bona fide transcription repressor of key glycolytic genes and its downregulation in human cancer contributes to tumor metabolism. As reduced expression of ZBTB7A is found only in a subset of human cancers, we explored alternative mechanisms of its inactivation by mining human cancer genome databases. We discovered recurrent somatic mutations of ZBTB7A in multiple types of human cancers with a marked enrichment of mutations within the zinc finger domain. Func ...[more]