Ontology highlight
ABSTRACT:
SUBMITTER: Cranston RD
PROVIDER: S-EPMC5850518 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Cranston Ross D RD Lama Javier R JR Richardson Barbra A BA Carballo-Diéguez Alex A Kunjara Na Ayudhya Ratiya Pamela RP Liu Karen K Patterson Karen B KB Leu Cheng-Shiun CS Galaska Beth B Jacobson Cindy E CE Parikh Urvi M UM Marzinke Mark A MA Hendrix Craig W CW Johnson Sherri S Piper Jeanna M JM Grossman Cynthia C Ho Ken S KS Lucas Jonathan J Pickett Jim J Bekker Linda-Gail LG Chariyalertsak Suwat S Chitwarakorn Anupong A Gonzales Pedro P Holtz Timothy H TH Liu Albert Y AY Mayer Kenneth H KH Zorrilla Carmen C Schwartz Jill L JL Rooney James J McGowan Ian I
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20170301 5
<h4>Background</h4>Human immunodeficiency virus (HIV) disproportionately affects men who have sex with men (MSM) and transgender women (TGW). Safe and acceptable topical HIV prevention methods that target the rectum are needed.<h4>Methods</h4>MTN-017 was a phase 2, 3-period, randomized sequence, open-label, expanded safety and acceptability crossover study comparing rectally applied reduced-glycerin (RG) 1% tenofovir (TFV) and oral emtricitabine/TFV disoproxil fumarate (FTC/TDF). In each 8-week ...[more]