Early Detection of A? Deposition in the 5xFAD Mouse by Amyloid PET.
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ABSTRACT:
SUBMITTER: Oh SJ
PROVIDER: S-EPMC5851318 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Early Detection of A<i>β</i> Deposition in the 5xFAD Mouse by Amyloid PET.
Oh Se Jong SJ Lee Hae-June HJ Kang Kyung Jun KJ Han Sang Jin SJ Lee Yong Jin YJ Lee Kyo Chul KC Lim Sang Moo SM Chi Dae Yoon DY Kim Kyeong Min KM Park Ji-Ae JA Choi Jae Yong JY
Contrast media & molecular imaging 20180228
<i>Purpose.</i><sup>18</sup>F-FC119S is a positron emission tomography (PET) tracer for imaging <i>β</i>-amyloid (A<i>β</i>) plaques in Alzheimer's disease (AD). The aim of this study is to evaluate the efficacy of <sup>18</sup>F-FC119S in quantitating A<i>β</i> deposition in a mouse model of early amyloid deposition (5xFAD) by PET. <i>Method</i>. Dynamic <sup>18</sup>F-FC119S PET images were obtained in 5xFAD (<i>n</i> = 5) and wild-type (WT) mice (<i>n</i> = 7). The brain PET images were spati ...[more]
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Project description:BACKGROUND:Florbetaben, a 18F-labeled stilbene derivative (Neuraceq®, formerly known as BAY-949172), is a diagnostic radiopharmaceutical developed to visualize ?-amyloid plaques in the brain. Here, we report a pilot study evaluating patients with suspected cardiac amyloidosis for systemic extent of disease. METHODS:We prospectively enrolled nine patients, 61-86 year old (mean?±?SD 69.4?±?8.6), referred from the cardiac amyloid clinic. First, dynamic imaging of the heart was acquired immediately after injection of 222-318.2 MBq (mean?±?SD 270.1?±?33.3) of 18F-florbetaben using the GE SIGNA PET/MRI. This was followed by a whole-body PET/MRI scan 60-146.4 min (mean?±?SD 98?±?33.4) after injection. Cardiac MRI sequences included ECG-triggered cine SSFP, T2-weighted, and late gadolinium-enhanced imaging. Whole-body MRI sequences included MRAC and axial T1-weighted imaging. RESULTS:High early uptake and delayed high uptake in the left ventricle correlated with amyloid deposition in five patients, while low uptake on early and delayed cardiac imaging was noted in four patients. Cardiac function measurements were successfully obtained in all participants. Areas of increased abnormal 18F-florbetaben accumulation were noted on delayed whole-body imaging in the bone marrow (seven patients), stomach (diffuse in five patients and focal in one patient), brain (five patients), salivary glands (three patients), tongue (three patients), spleen (three patients), skeletal muscles (three patients), ocular muscles (two patients), thyroid (two patients), pleura (two patients), kidneys (two patients), and lungs (two patients). CONCLUSIONS:Whole-body 18F-florbetaben PET/MRI is promising for localization of systemic amyloid deposition. This technique may provide important structural and functional information regarding the organs involved by disease, with potential to guide biopsy and evaluate response to treatment. TRIAL REGISTRATION:Clinicaltrials.gov registration: NCT03119558 .
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