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Genome-wide association study of maternal genetic effects and parent-of-origin effects on food allergy.

ABSTRACT: Previous genetic studies of food allergy (FA) have mainly focused on inherited genotypic effects. The role of parental genotypic effects remains largely unexplored. Leveraging existing genome-wide association study (GWAS) data generated from the Chicago Food Allergy Study, we examined maternal genotypic and parent-of-origin (PO) effects using multinomial likelihood ratio tests in 588 complete and incomplete Caucasian FA trios. We identified 1 single nucleotide polymorphism with significant (P?

SUBMITTER: Liu X

PROVIDER: S-EPMC5851764 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Genome-wide association study of maternal genetic effects and parent-of-origin effects on food allergy.

Liu Xin X Hong Xiumei X Tsai Hui-Ju HJ Mestan Karen K KK Shi Min M Kefi Amira A Hao Ke K Chen Qi Q Wang Guoying G Caruso Deanna D Geng Hua H Gao Yufeng Y He Jianlin J Kumar Rajesh R Wang Hongjian H Yu Yunxian Y Bartell Tami T Tan Xiao-Di XD Schleimer Robert P RP Weeks Daniel E DE Pongracic Jacqueline A JA Wang Xiaobin X

Medicine 20180301 9

Previous genetic studies of food allergy (FA) have mainly focused on inherited genotypic effects. The role of parental genotypic effects remains largely unexplored. Leveraging existing genome-wide association study (GWAS) data generated from the Chicago Food Allergy Study, we examined maternal genotypic and parent-of-origin (PO) effects using multinomial likelihood ratio tests in 588 complete and incomplete Caucasian FA trios. We identified 1 single nucleotide polymorphism with significant (P < ...[more]

PMID: 29489655

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