Ontology highlight
ABSTRACT:
SUBMITTER: Cuellar Partida G
PROVIDER: S-EPMC6077796 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Cuellar Partida Gabriel G Laurin Charles C Ring Susan M SM Gaunt Tom R TR McRae Allan F AF Visscher Peter M PM Montgomery Grant W GW Martin Nicholas G NG Hemani Gibran G Suderman Matthew M Relton Caroline L CL Davey Smith George G Evans David M DM
Human molecular genetics 20180801 16
Genomic imprinting is an epigenetic mechanism leading to parent-of-origin silencing of alleles. So far, the precise number of imprinted regions in humans is uncertain. In this study, we leveraged genome-wide DNA methylation in whole blood measured longitudinally at three time points (birth, childhood and adolescence) and genome-wide association studies (GWAS) data in 740 mother-child duos from the Avon Longitudinal Study of parents and children to identify candidate imprinted loci. We reasoned t ...[more]