Ontology highlight
ABSTRACT:
SUBMITTER: Lu XF
PROVIDER: S-EPMC5852132 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Lu Xu-Feng XF Cao Xiao-Yue XY Zhu Yong-Jie YJ Wu Zhen-Ru ZR Zhuang Xiang X Shao Ming-Yang MY Xu Qing Q Zhou Yong-Jie YJ Ji Hong-Jie HJ Lu Qing-Richard QR Shi Yu-Jun YJ Zeng Yong Y Bu Hong H
Cell death & disease 20180314 3
Histone deacetylase 3 (HDAC3) plays pivotal roles in cell cycle regulation and is often aberrantly expressed in various cancers including hepatocellular carcinoma (HCC), but little is known about its role in liver regeneration and liver cancer cells proliferation. Using an inducible hepatocyte-selective HDAC3 knockout mouse, we find that lack of HDAC3 dramatically impaired liver regeneration and blocked hepatocyte proliferation in the G1 phase entry. HDAC3 inactivation robustly disrupted the sig ...[more]