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Enantioselective Borylation of Aromatic C-H Bonds with Chiral Dinitrogen Ligands.

ABSTRACT: The borylation of C-H bonds catalyzed by transition metals has been investigated extensively in the past two decades, but no iridium-catalyzed enantioselective borylation of C-H bonds has been reported. We report a set of iridium-catalyzed enantioselective borylations of aromatic C-H bonds. This reaction relies on a set of newly developed chiral quinolyl oxazoline ligands. This process proceeds under mild conditions with good to excellent enantioselectivity, and the borylated products can be converted to enantioenriched derivatives containing new C-O, C-C, C-Cl, or C-Br bonds.

SUBMITTER: Su B

PROVIDER: S-EPMC5852249 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Enantioselective Borylation of Aromatic C-H Bonds with Chiral Dinitrogen Ligands.

Su Bo B Zhou Tai-Gang TG Xu Pei-Lin PL Shi Zhang-Jie ZJ Hartwig John F JF

Angewandte Chemie (International ed. in English) 20170516 25

The borylation of C-H bonds catalyzed by transition metals has been investigated extensively in the past two decades, but no iridium-catalyzed enantioselective borylation of C-H bonds has been reported. We report a set of iridium-catalyzed enantioselective borylations of aromatic C-H bonds. This reaction relies on a set of newly developed chiral quinolyl oxazoline ligands. This process proceeds under mild conditions with good to excellent enantioselectivity, and the borylated products can be con ...[more]

PMID: 28508564

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