Ontology highlight
ABSTRACT:
SUBMITTER: Yi Z
PROVIDER: S-EPMC5852415 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Yi Zhongzhen Z Prinzing Brooke L BL Cao Felicia F Gottschalk Stephen S Krenciute Giedre G
Molecular therapy. Methods & clinical development 20180202
Glioblastoma is the most aggressive primary brain tumor in humans and is virtually incurable with conventional therapies. Chimeric antigen receptor (CAR) T cell therapy targeting the glioblastoma antigen EphA2 is an attractive approach to improve outcomes because EphA2 is expressed highly in glioblastoma but only at low levels in normal brain tissue. Building upon our previous findings in this area, we generated and evaluated a panel of EphA2-specific CARs. We demonstrate here that T cells expre ...[more]