Optimizing intracellular signaling domains for CAR NK cells in HIV immunotherapy: a comprehensive review.
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ABSTRACT:
SUBMITTER: Zenere G
PROVIDER: S-EPMC7065919 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
Optimizing intracellular signaling domains for CAR NK cells in HIV immunotherapy: a comprehensive review.
Zenere Giorgio G Olwenyi Omalla Allan OA Byrareddy Siddappa N SN Braun Stephen E SE
Drug discovery today 20190213 4
Natural killer (NK) cells are innate immune lymphocytes with a key role in host defense against HIV infection. Recent advances in chimeric antigen receptors (CARs) have made NK cells a prime target for expressing recombinant receptors capable of redirecting NK cytotoxic functions towards HIV-infected cells. In this review, we discuss the role of NK cells in HIV and the mechanisms of actions of HIV-targeting CAR strategies. Furthermore, we also review NK cells signal transduction and its applicat ...[more]
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