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Chloro-Furanocembranolides from Leptogorgia sp. Improve Pancreatic Beta-Cell Proliferation.

ABSTRACT: Two new chloro-furanocembranolides (1, 2) and two new 1,4-diketo cembranolides (3, 4) were isolated from the crude extract of Leptogorgia sp. together with a new seco-furanocembranolide (5) and the known Z-deoxypukalide (6), rubifolide (7), scabrolide D (8) and epoxylophodione (9). Their structures were determined based on spectroscopic evidence. Four compounds: 1, 2, 7 and 8 were found to activate the proliferation of pancreatic insulin-producing (beta) cells.

SUBMITTER: Gallardo AB

PROVIDER: S-EPMC5852477 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Chloro-Furanocembranolides from Leptogorgia sp. Improve Pancreatic Beta-Cell Proliferation.

Gallardo Amalia B AB Díaz-Marrero Ana R AR de la Rosa José M JM de la Rosa José M JM D'Croz Luis L Perdomo Germán G Cózar-Castellano Irene I Darias José J Cueto Mercedes M

Marine drugs 20180202 2

Two new chloro-furanocembranolides (1, 2) and two new 1,4-diketo cembranolides (3, 4) were isolated from the crude extract of Leptogorgia sp. together with a new seco-furanocembranolide (5) and the known Z-deoxypukalide (6), rubifolide (7), scabrolide D (8) and epoxylophodione (9). Their structures were determined based on spectroscopic evidence. Four compounds: 1, 2, 7 and 8 were foun ...[more]

PMID: 29393907

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