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Chlorinated Azaphilone Pigments with Antimicrobial and Cytotoxic Activities Isolated from the Deep Sea Derived Fungus Chaetomium sp. NA-S01-R1.

ABSTRACT: Four novel compounds, chaephilone C (1), chaetoviridides A-C (2-4), were obtained from the culture of a deep sea derived fungus Chaetomium sp. NA-S01-R1, together with four known compounds-chaetoviridin A (5), chaetoviridine E (6), chaetomugilin D (7) and cochliodone A (8). Their structures, including absolute configurations, were assigned based on NMR, MS and time-dependent density functional theory (TD-DFT) ECD calculations. A plausible biogenetic pathway for compounds 1-3 was proposed. Compounds 2 and 3 exhibited antibacterial activities against Vibrio rotiferianus and Vibrio vulnificus. Compounds 1, 3 and 4 displayed similar anti-methicillin resistant Staphylococcus aureus (anti-MRSA) activities in comparison to chloramphenicol. Compound 2 showed the most potent cytotoxic activities towards the Hep G2 cell and compounds 1 and 3 demonstrated relatively stronger cytotoxic activities than the other compounds against the HeLa cell.

SUBMITTER: Wang W 

PROVIDER: S-EPMC5852489 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Chlorinated Azaphilone Pigments with Antimicrobial and Cytotoxic Activities Isolated from the Deep Sea Derived Fungus Chaetomium sp. NA-S01-R1.

Wang Weiyi W   Liao Yanyan Y   Chen Ruixuan R   Hou Yanping Y   Ke Wenqian W   Zhang Beibei B   Gao Maolin M   Shao Zongze Z   Chen Jianming J   Li Fang F  

Marine drugs 20180213 2

Four novel compounds, chaephilone C (<b>1</b>), chaetoviridides A-C (<b>2</b>-<b>4</b>), were obtained from the culture of a deep sea derived fungus <i>Chaetomium</i> sp. NA-S01-R1, together with four known compounds-chaetoviridin A (<b>5</b>), chaetoviridine E (<b>6</b>), chaetomugilin D (<b>7</b>) and cochliodone A (<b>8</b>). Their structures, including absolute configurations, were assigned based on NMR, MS and time-dependent density functional theory (TD-DFT) ECD calculations. A plausible b  ...[more]

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