Ontology highlight
ABSTRACT:
SUBMITTER: Ming Z
PROVIDER: S-EPMC5853865 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Ming Zhenping Z Gong Ai-Yu AY Wang Yang Y Zhang Xin-Tian XT Li Min M Mathy Nicholas W NW Strauss-Soukup Juliane K JK Chen Xian-Ming XM
The Journal of infectious diseases 20171201 1
Intestinal infection by Cryptosporidium parvum causes inhibition of epithelial turnover, but underlying mechanisms are unclear. Previous studies demonstrate that a panel of parasite RNA transcripts of low protein-coding potential are delivered into infected epithelial cells. Using in vitro and in vivo models of intestinal cryptosporidiosis, we report here that host delivery of parasite Cdg7_FLc_1000 RNA results in inhibition of epithelial cell migration through suppression of the gene encoding s ...[more]