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Age-Related Differences in Influenza B Infection by Lineage in a Community-Based Sentinel System, 2010-2011 to 2015-2016, Canada.

ABSTRACT: Age-related differences in influenza B lineage detection were explored in the community-based Canadian Sentinel Practitioner Surveillance Network (SPSN) from 2010-2011 to 2015-2016. Whereas >80% of B(Victoria) cases were <40 years old, B(Yamagata) cases showed a bimodal age distribution with 27% who were <20 years old and 61% who were 30-64 years old, but with a notable gap in cases between 20 and 29 years old (4%). Overall, the median age was 20 years lower for B(Victoria) vs B(Yamagata) cases (20 vs 40 years; P < .01). Additional phylodynamic and immuno-epidemiological research is needed to understand age-related variation in influenza B risk by lineage, with potential implications for prevention and control across the lifespan.

SUBMITTER: Skowronski DM 

PROVIDER: S-EPMC5853978 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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Age-Related Differences in Influenza B Infection by Lineage in a Community-Based Sentinel System, 2010-2011 to 2015-2016, Canada.

Skowronski Danuta M DM   Chambers Catharine C   De Serres Gaston G   Sabaiduc Suzana S   Winter Anne-Luise AL   Dickinson James A JA   Gubbay Jonathan B JB   Fonseca Kevin K   Drews Steven J SJ   Charest Hugues H   Martineau Christine C   Krajden Mel M   Petric Martin M   Bastien Nathalie N   Li Yan Y  

The Journal of infectious diseases 20170901 6

Age-related differences in influenza B lineage detection were explored in the community-based Canadian Sentinel Practitioner Surveillance Network (SPSN) from 2010-2011 to 2015-2016. Whereas >80% of B(Victoria) cases were <40 years old, B(Yamagata) cases showed a bimodal age distribution with 27% who were <20 years old and 61% who were 30-64 years old, but with a notable gap in cases between 20 and 29 years old (4%). Overall, the median age was 20 years lower for B(Victoria) vs B(Yamagata) cases  ...[more]

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