Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Z
PROVIDER: S-EPMC5854348 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Zhang Zengli Z Wang Huiqian H Ding Qifeng Q Xing Yufei Y Xu Zhonghua Z Lu Chun C Luo Dongdong D Xu Longjiang L Xia Wei W Zhou Caicun C Shi Minhua M
PloS one 20180315 3
The prognosis of advanced non-small cell lung cancer (NSCLC) patients is poor. One of the reasons for this hampered progress has been a lack of in vitro models that would faithfully recapitulate the heterogeneity of tumors and response to treatment. In this study, surgically resected tumors were obtained from patients with stage I/II NSCLC during curative-intent surgery. Using a 3D patient-derived tumor spheroids culture system, our results demonstrate successful long-term expansion of primary N ...[more]