Ontology highlight
ABSTRACT:
SUBMITTER: Surina
PROVIDER: S-EPMC9988482 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Surina Tanggis Suzuki Tomoko T Hisata Shu S Fujita Kazutaka K Fujiwara Satomi S Liu Fangyuan F Fukushima Noriyoshi N Suzuki Takuji T Mato Naoko N Hagiwara Koichi K
Heliyon 20230218 3
Cancer cells harbor many genetic mutations and gene expression profiles different from normal cells. Patient-derived cancer cells (PDCC) are preferred materials in cancer study. We established patient-derived spheroids (PDSs) and patient-derived organoids (PDOs) from PDCCs isolated from the malignant pleural effusion in 8 patients. The morphologies suggested that PDSs may be a model of local cancer extensions, while PDOs may be a model of distant cancer metastases. The gene expression profiles d ...[more]