A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers.
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ABSTRACT:
SUBMITTER: Thibaudeau TA
PROVIDER: S-EPMC5854577 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Publications
A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers.
Thibaudeau Tiffany A TA Anderson Raymond T RT Smith David M DM
Nature communications 20180315 1
Protein accumulation and aggregation with a concomitant loss of proteostasis often contribute to neurodegenerative diseases, and the ubiquitin-proteasome system plays a major role in protein degradation and proteostasis. Here, we show that three different proteins from Alzheimer's, Parkinson's, and Huntington's disease that misfold and oligomerize into a shared three-dimensional structure potently impair the proteasome. This study indicates that the shared conformation allows these oligomers to ...[more]
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