Ontology highlight
ABSTRACT:
SUBMITTER: Gillotin S
PROVIDER: S-EPMC5854709 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Gillotin Sébastien S Davies John D JD Philpott Anna A
Scientific reports 20180315 1
The proneural transcription factor Ascl1 is a master regulator of neurogenesis, coordinating proliferation and differentiation in the central nervous system. While its expression is well characterised, post-translational regulation is much less well understood. Here we demonstrate that a population of chromatin-bound Ascl1 can be found associated with short chains of ubiquitin while cytoplasmic Ascl1 harbours much longer ubiquitin chains. Only cytoplasmic ubiquitylation targets Ascl1 for destruc ...[more]