Ontology highlight
ABSTRACT:
SUBMITTER: Santos JM
PROVIDER: S-EPMC5855115 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Santos Joana Mendonca JM Josling Gabrielle G Ross Philipp P Joshi Preeti P Orchard Lindsey L Campbell Tracey T Schieler Ariel A Cristea Ileana M IM Llinás Manuel M
Cell host & microbe 20170601 6
Obligate intracellular parasites must efficiently invade host cells in order to mature and be transmitted. For the malaria parasite Plasmodium falciparum, invasion of host red blood cells (RBCs) is essential. Here we describe a parasite-specific transcription factor PfAP2-I, belonging to the Apicomplexan AP2 (ApiAP2) family, that is responsible for regulating the expression of genes involved in RBC invasion. Our genome-wide analysis by ChIP-seq shows that PfAP2-I interacts with a specific DNA mo ...[more]