Ontology highlight
ABSTRACT:
SUBMITTER: Chinnadurai R
PROVIDER: S-EPMC5855117 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Chinnadurai Raghavan R Rajan Devi D Qayed Muna M Arafat Dalia D Garcia Marco M Liu Yifei Y Kugathasan Subra S Anderson Larry J LJ Gibson Greg G Galipeau Jacques J
Cell reports 20180201 9
Assays that can characterize MSC immune potency need to be identified for use in advanced clinical trials. MSCs possess a number of putative regenerative and immunomodulatory properties, and an assay matrix approach may best capture involved effector pathways. We have tested two assay systems to measure the potency of MSCs derived from human subjects: MSC secretome analysis and a quantitative RNA-based array for genes specific to immunomodulatory and homing properties of MSCs. Secretome analysis ...[more]